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Preface...
Table of Contents...
Contributing Authors...
1. G-Quadruplex DNA and RNA
Danzhou Yang
2. CD Study of the G-Quadruplex Conformation
Iva Kejnovská, Daniel Renciuk, Jan Palacký, and Michaela Vorlícková
3. Revealing the Energetics of Ligand-Quadruplex Interactions using Isothermal Titration Calorimetry
Andrea Funke and Klaus Weisz
4. Biosensor-Surface Plasmon Resonance: Label Free Method for Investigation of Small Molecule-Quadruplex Nucleic Acid Interactions
Ananya Paul, Caterina Musetti, Rupesh Nanjunda, and W. David Wilson
5. Putting a New Spin of G-Quadruplex Structure and Binding by Analytical Ultracentrifugation
William L. Dean, Robert D. Gray, Lynn DeLeeuw, Robert C. Monsen, and Jonathan B. Chaires
6. Mass Spectroscopic Study of G-Quadruplex
Huihui Li
7. G-Quadruplex Stability from DSC Measurements
San Hadzi, Matjaz Boncina, and Jurij Lah
8. X-Ray Crystallographic Studies of G-Quadruplex Structures
Gary N. Parkinson and Gavin W. Collie
9. NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds
Clement Lin, Jonathan Dickerhoff, and Danzhou Yang
10. Using Molecular Dynamics Free Energy Simulation to Compute Binding Affinities of DNA G-Quadruplex Ligands
Nanjie Deng
11. Electrophoretic Mobility Shift Assay and Dimethyl Sulfate Footprinting for Characterization of G-Quadruplexes and G-Quadruplex-Protein Complexes
Buket Onel, Guanhui Wu, Daekyu Sun, Clement Lin, and Danzhou Yang
12. A DNA Polymerase Stop Assay for Characterization of G-Quadruplex Formation and Identification of G-Quadruplex-Interactive Compounds
Guanhui Wu and Haiyong Han
13. Chromatin Immunoprecipitation Assay to Analyze the Effect of G-Quadruplex Interactive Agents on the Binding of RNA Polymerase II and Transcription Factors to a Target Promoter Region
Daekyu Sun
14. Characterization of Co-Transcriptional Formation of G-Quadruplexes in Double-Stranded DNA
Ke-wei Zheng, Jia-yu Zhang, and Zheng Tan
15. Quantitative Analysis of Stall of Replicating DNA Polymerase by G-Quadruplex Formation
Shuntaro Takahashi and Naoki Sugimoto
16. Single-Molecule Investigations of G-Quadruplex
Shankar Mandal, Mohammed Enamul Hoque, and Hanbin Mao
17. Direct Observation of the Formation and Dissociation of Double-Stranded DNA Containing G-Quadruplex/i-motif Sequences in the DNA Origami Frame using High-Speed AFM
Masayuki Endo, Xiwen Xing, and Hiroshi Sugiyama
18. G-Quadruplex and Protein Binding by Single-Molecule FRET Microscopy
Chun-Ying Lee, Christina McNerney, and Sua Myong
19. High-Throughput Screening of G-Quadruplex Ligands by FRET Assay
Kaibo Wang, Daniel P. Flaherty, Lan Chen, and Danzhou Yang
20. Targeting G-Quadruplexes with PNA Oligomers
Bruce A. Armitage
21. Primer-Modified G-Quadruplex-Au Nanoparticles for Colorimetric Assay of Human Telomerase Activity and Initial Screening of Telomerase Inhibitors
Fang Pu, Jinsong Ren, and Xiaogang Qu
22. Heme.G-Quadruplex DNAzymes: Conditions for Maximizing their Peroxidase Activity
Nisreen Shumayrikh and Dipankar Sen
23. In Vivo Chemical Probing for G-Quadruplex Formation
Fedor Kouzine, Damian Wojtowicz, Arito Yamane, Rafael Casellas, Teresa M. Przytycka, and David L. Levens
24. G-Quadruplex Visualization In Cells via Antibody and Fluorescence Probe
Matteo Nadai and Sara N. Richter
25. In Cell NMR Spectroscopy: Investigation of G-Quadruplex Structures inside Living Xenopus laevis Oocytes
Michaela Krafcikova, Robert Hänsel-Hertsch, Lukas Trantirek, and Silvie Foldynova-Trantirkova
26. 19F NMR Spectroscopy for the Analysis of DNA G-Quadruplex Structures using 19F-labeled Nucleobase
Takumi Ishizuka, Hong-Liang Bao, and Yan Xu
